| 探寻免疫相关重要蛋白质的脉络——免疫相关重要蛋白质的生物学研究进展 |
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| 引用本文： | 郑晓东,;范祖森,;张纪岩,;陈涛涌.探寻免疫相关重要蛋白质的脉络——免疫相关重要蛋白质的生物学研究进展[J].生命科学,2014(12):1278-1283. |
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| 作者姓名： | 郑晓东 ;范祖森 ;张纪岩 ;陈涛涌 |
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| 作者单位： | [1]中国科学技术大学免疫学研究所,合肥230022; [2]中国科学院生物物理研究所,北京100101; [3]中国人民解放军军事医学科学院,北京100850; [4]中国人民解放军第二军医大学医学免疫学国家重点实验室暨第二军医大学免疫学研究所,上海200433 |
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| 基金项目： | 基金项目：国家重大科学研究计划（2010CB911900） |
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| 摘 要： | 深入认识免疫功能的调节机制有助于预见感染、肿瘤和自身免疫等疾病的发展方向,并可能针对其具体的调节靶点和途径加以调控。国家重大科学研究项目"免疫相关重要蛋白质的生物学研究",以发现新的免疫相关蛋白质及其复合体为切入点,探讨其在免疫识别、免疫应答/耐受、免疫调节过程中的功能,从而掌握免疫过程及其调节的特点和规律,为攻克感染、肿瘤或自身免疫疾病提供重要的理论基础,为相应的干预治疗提供新的靶点和策略。将对项目启动5年来开展的研究内容及取得的研究成果进行介绍。
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| 关 键 词： | 免疫 蛋白质 生物学功能 |
Advances in biological research of immune-related key proteins |
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| Institution: | ZHENG Xiao-Dong, FAN Zu-Sen , ZHANG Ji-Yan, CHEN Tao-Yong (1 Institute of Immunology, University of Science and Technology of China, Hefei 230022, China; 2 Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 3 Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing 100850, China; 4 State Key Laboratory of Medical Immunology ＆ Institute of Immunology, Second Military Medical University, Shanghai 200433, China) |
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| Abstract: | A profound understanding of the regulatory mechanisms of immune function will contribute to predict the development trend of the infection, tumor and autoimmune diseases, and make it possible to control these diseases by targeting specific molecules and pathways. National Basic Research Program of China ＂Biological research of the immune-related key proteins＂, starting with the discovery of new immune proteins and its complex, aims to explore their function in the immune recognition, immune response/tolerance, and immune regulation, master the characteristics and rules of immune process and regulation, in order to provide important theoretical basis to conquer infection, tumor and autoimmune disease, and provide new targets and strategies for the intervention and treatment. This article will review the research progress of the five-year project. |
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| Keywords: | immunity protein biological function |
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