泛素介导的蛋白质降解系统——从基础研究到临床应用

20世纪60～80年代,大多数生物科研人员都致力于核酸和遗传信息传递的研究。蛋白质降解被认为是非特异的过程,因此没有人感兴趣。泛素修饰的发现使蛋白质降解领域发生革命性的变化,人们逐渐认识到蛋白质降解是一个特异的受严格调控的过程。细胞内蛋白质降解事件的发生会调节许多生命过程,如细胞增殖、分化、衰老和死亡。细胞内蛋白质降解调控异常也会引发多种疾病,包括癌症和神经退行性疾病。人们对细胞内蛋白质降解的研究已经取得一定成果,但是还有很多问题没有解决,全面解读该过程还需要更多的努力和探索。

The ubiquitin proteolytic system-from bench to the bedside

Between the sixties and eighties,most life scientists focused their attention on studies of nucleic acids and the translation of the coded information.Protein degradation was a neglected area,considered to be a nonspecific,dead-end process.While it was known that proteins do turnover,the large extent and high specificity of the process-whereby distinct proteins have half-lives that range from a few minutes to several days-was not appreciated.The discovery of the complex cascade of ubiquitin pathway revoluti...