| 人乳头状瘤病毒感染与肺癌关系的研究进展 |
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| 引用本文： | 李刚,何丽,唐旭东.人乳头状瘤病毒感染与肺癌关系的研究进展[J].生命科学,2011(3):261-266. |
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| 作者姓名： | 李刚 何丽 唐旭东 |
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| 作者单位： | 广东医学院生物化学与分子生物学教研室; |
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| 基金项目： | 国家自然科学基金项目(30872944,81073103); 广东省第二批科学事业费科技计划项目(2009B030801330); 广东省中医药局建设中医药强省科研项目(2008166); 东莞市高等院校科研机构和医疗卫生单位科技计划项目(2008108101047) |
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| 摘 要： | 近年越来越多的研究发现肺癌组织中有人乳头状瘤病毒（human papillomavirus,HPV）DNA和癌蛋白的检出,其检出率具有地域差异性,但不同地方HPV检出亚型具有高度的一致性,主要是高危型HPV-16和HPV-18。HPV可能主要通过血液循环从宫颈癌病灶等原发部位转移到肺,从而可能诱发肺癌的发生。HPV诱发肺癌的机制可能与影响p53的失活及端粒酶的激活等有关。
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| 关 键 词： | 人乳头状瘤病毒 肺癌 p53 端粒酶 |
Research progress of relationship between human papillomavirus infection and lung cancer |
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| LI Gang,HE Li,TANG Xu-dong.Research progress of relationship between human papillomavirus infection and lung cancer[J].Chinese Bulletin of Life Sciences,2011(3):261-266. |
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| Authors: | LI Gang HE Li TANG Xu-dong |
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| Institution: | LI Gang,HE Li,TANG Xu-dong*(Department of Biochemistry and Molecular Biology,Guangdong Medical College,Zhanjiang 524023,China) |
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| Abstract: | In recent years,a number of studies showed that HPV-DNA and oncoproteins were detected in lung cancer tissues.The detection rate was from 0 to 80% with the differences of regions,but there was no significant difference between HPV subtypes in lung cancer,and high-risk types HPV-16 and-18 were most frequently at present.HPV infected lung from primary cervical cancer may mainly through blood circulation.The mechanism of HPV-induced lung cancer may be related to inactivation of p53 and activation of telomerase... |
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| Keywords: | human papillomavirus lung cancer p53 telomerase |
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