肝型脂肪酸结合蛋白研究进展

肝型脂肪酸结合蛋白（liver fatty acid binding protein,L-FABP）是脂肪酸结合蛋白（fatty acid binding proteins,FABPs）家族重要的成员,在肝脏、小肠、肾脏等组织中均有表达。L-FABP在不饱和脂肪酸、饱和脂肪酸、胆固醇、胆汁酸等转运过程中扮演重要角色。目前研究显示L-FABP在脂肪肝、肝硬化以及肝癌发生发展中起到重要作用,并有望作为肝损伤的早期检测指标。此外,新近研究发现尿中L-FABP水平还可以用于预测1型糖尿病患者的临床结局。在2型糖尿病中,尿中L-FABP与糖尿病性肾病的病程有密切关系。主要就L-FABP的特性、结构及其与疾病的关系做一综述。

Progress in liver type fatty acid binding protein

Liver fatty acid binding protein（L-FABP） which mainly expresses in liver,intestine and kidney,is an important member of FABP family.It is found that L-FABP is related to the translocation of saturated fatty acid,unsaturated fatty acid,cholesterol,bile acid and so on.Many studies have indicated that L-FABP was involved in fatty liver,cirrhosis and hepatocarcinoma.Moreover,L-FABP can be an appropriate biomarker in predicting the progression of liver injury.Recent researches have demonstrated that u-LFABP might be a new tool in the prediction of diabetic nephropathy in type 1 diabetic patients.Besides,L-FABP levels reflect the severity of diabetic nephropathy accurately in type 2 diabetes.This article aims to review the characteristics,conformation of L-FABP,and its relationship with some diseases.