| NOX家族蛋白的研究进展 |
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| 引用本文： | 韩晓燕,高丽萍,刘箐.NOX家族蛋白的研究进展[J].生命科学,2012(6):568-577. |
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| 作者姓名： | 韩晓燕 高丽萍 刘箐 |
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| 作者单位： | [1]兰州大学基础医学院生物化学与分子生物学研究所,兰州730000 [2]上海理工大学医疗器械与食品学院,上海200093 |
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| 基金项目： | 国家自然科学基金项目（30870586,KJCX1-YW-004-2）;国家重点基础研究发展计划（“973”项目）（2010CB83-4200） |
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| 摘 要： | NADPH氧化酶催化亚基gp91phox（NOX2）及其同源物NOX1、NOX3、NOX4、NOX5、DUOX1和DUOX2统称为NOX家族,它们作为NADPH酶的核心亚基,是该酶发挥作用的关键。NOX家族几乎存在于所有的细胞,吞噬细胞中NADPH氧化酶生成的ROS主要起细胞防御功能,与此不同的是非吞噬细胞中NADPH氧化酶产生的ROS作为信号分子,参与机体内信号转导途径,调节细胞分化、增殖、衰老和凋亡等活动;当NOX家族蛋白异常表达,ROS水平急剧增加时,则能诱导机体内多种疾病的发生。
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| 关 键 词： | NOX家族 ROS 表达 结构 活化 功能 |
The development of NOX family proteins |
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| HAN Xiao-Yan,GAO Li-Ping,LIU Qing.The development of NOX family proteins[J].Chinese Bulletin of Life Sciences,2012(6):568-577. |
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| Authors: | HAN Xiao-Yan GAO Li-Ping LIU Qing |
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| Institution: | 1 Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;2 School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China) |
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| Abstract: | The catalytic subunit gp91phox（NOX2） of NADPH oxidase and its homologues NOX1,NOX3,NOX4,NOX5,DUOX1 and DUOX2 are collectively referred to as the NOX family.NOX family proteins play a key role in NADPH oxidase function as the core subunits of the NADPH enzyme.In recent years,a large number of studies show that NOX family proteins exist in almost all cells.NADPH oxidase-generated ROS plays a cellular defense function in the phagocytic cells,the difference is that the ROS is generated by NOX family in non-phagocytic cells as a signaling molecule,involving in signal transduction and regulating cell differentiation,proliferation,senescence and apoptosis.When the abnormal expression of NOX family proteins lead to a sharp increase in ROS levels,the oxidative stress can induce many diseases. |
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| Keywords: | NOX family ROS structure expression activation function |
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