| COX-2与糖尿病并发症关系研究进展 |
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| 引用本文： | 张一弛,牟艳玲,解砚英.COX-2与糖尿病并发症关系研究进展[J].生命科学,2012(1):63-68. |
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| 作者姓名： | 张一弛 牟艳玲 解砚英 |
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| 作者单位： | 山东省医学科学院药物研究所,山东省罕少见病重点实验室,济南250062 |
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| 基金项目： | 国家自然科学基金项目（30701022）; 山东省自然科学基金项目（Y2007C156） |
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| 摘 要： | 糖尿病是一种慢性、低度炎症性疾病。多种因素刺激下,环氧化酶COX-2在胰岛及多种组织中高水平表达。它通过与炎症因子和炎症介质,如一氧化氮、核因子-κB、前列腺素E等相互作用,对相应组织产生作用,从而促进了糖尿病并发症的发生和发展。对COX-2的研究可进一步揭示糖尿病并发症发生的分子机制,为预防和治疗糖尿病并发症提供新的思路。
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| 关 键 词： | COX-2 糖尿病 糖尿病并发症 炎症反应 |
Research progress in relations between cyclooxygenase 2 and diabetes mellitus complications |
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| ZHANG Yi-Chi,MOU Yan-Ling,XIE Yan-Ying.Research progress in relations between cyclooxygenase 2 and diabetes mellitus complications[J].Chinese Bulletin of Life Sciences,2012(1):63-68. |
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| Authors: | ZHANG Yi-Chi MOU Yan-Ling XIE Yan-Ying |
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| Institution: | (Key Laboratory for Rare Disease of Shandong Province,Depantment of Pharmacology,Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,China) |
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| Abstract: | Recently,diabetes mellitus is viewed as a chronic and low level inflammation disease.Stimulated by several factors,cyclooxygenase-2（COX-2） is over expressed in pancreatic cells and other tissues.Interacting with some inflammatory factors and inflammatory mediators,such as nitric oxide,nuclear factor-κB,and prostaglandin E,it can produce the effects on corresponding tissues.COX-2 plays a crucial role in the pathogenesis and progress of diabetic complications.Further researches of COX-2 will be helpful in revealing the molecular mechanisms of diabetes complications,and will provide us a new way to prevent and treat diabetes mellitus. |
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| Keywords: | COX-2 diabetes mellitus diabetic complications inflammation |
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