神经递质转运蛋白在应激性心肌病发病中的潜在作用

应激性心肌病是强烈应激诱发的心血管急症,自20世纪90年代初Dote首次报告后,世界各地临床报告病例逐年攀升。发病机制迄今尚不完全清楚,但交感神经过度激活,大量释放去甲肾上腺素在本病发生中起重要作用。根据相关研究进展,主要综述神经递质转运蛋白调控神经递质及交感神经活性在这一神经源性心脏病中可能发挥的重要作用。

Potential role of neurotransmitter transporters on stress cardiomyopathy

Stress cardiomyopathy is an acute severe cardiovascular syndrome triggered by an emotionally or physically stressful event,also known as takotsubo cardiomyopathy has aroused interest in the cardiology community since it was first described by Dote in Japan in 1990.An increasing number of cases of the cardiomyopathy,mainly occurring in elderly women recently,have been documented in many parts of the world.Although the exact mechanism of stress cardiomyopathy remains not fully understood,it appears that the activation of the sympathetic nervous system,resulting in a surge of catecholamines due to severe emotional or acute physical disease,probably plays a central role in the pathology of this condition.This review primarily addresses the potential role of neurotransmitter transporters involved with pathogenesis of the neurogenic heart disease.