SR蛋白家族在RNA剪接中的调控作用

SR蛋白家族成员都具有一个富含丝氨酸/精氨酸(S/R)重复序列的RS结构域,在RNA剪接体的组装和选择性剪接的调控过程中具有重要的作用。绝大多数SR蛋白是生存的必需因子,通过其RS结构域和特有的其他结构域,实现与前体mRNA的特异性序列或其他剪接因子的相互作用,协同完成剪接位点的正确选择或促进剪接体的形成。深入研究SR蛋白家族在RNA选择性剪接中的调控机制,可以促进以疾病治疗或害虫防治为目的的应用研究。该文总结了SR蛋白家族在基础研究和应用方面的进展。

Function of SR protein family in pre-mRNA splicing

Members of SR protein family,consist of at least one RS domain that enriched with serine/arginine repeats,have been demonstrated to play important roles in both assembly of spliceosome and regulation of alternative splicing. Most of them are essential for high eukaryotes. They interact with specific RNA regions of pre-mRNA or other splicing factors through their RNA binding domain and RS domain,contributing to intron selection and facilitating spliceosome assembly. Address functions of SR proteins in the regulation of alternative splicing will benefit many studies,such as disease therapy and pest control.