记忆性T细胞的形成、维持和功能

免疫记忆是指机体在对某一抗原产生特异性识别及应答的同时,记住该抗原,当再次遭遇同一抗原时,能发生快速和强烈的免疫应答。树突状细胞吞噬病原微生物后,通过主要组织相容性复合体分子提呈抗原短肽段,与T细胞相互作用。在T细胞抗原受体信号和共刺激信号的协同作用下,抗原特异性T细胞增殖,收缩,小部分细胞作为记忆细胞长期存活。免疫记忆T细胞在表型特征和功能上都存在多样性。深入研究机体记忆性T细胞的特征,不仅能指导新型疫苗的设计,而且可望帮助治疗疾病。

Generation, maintenance and function of memory T cells

Immunological memory is the ability to make a second and more effective immune response to an antigen that encountered previously. Antigen is processed to short peptides and presented by DCs on MHC molecules to initiate the responses of T cells. A TCR signal with co-stimuli leads to clonal expansion of antigen-specific T cells and follows a phase of contraction, in which most short-lived antigen-specific effector T cells die. Some of these cells survive and form long-lived memory cells. Memory cells are het...