Institution: | aDepartment of Chemical Engineering, Kwangwoon University, Seoul 139-701, Republic of Korea bBioinformatix Inc., Eighth Floor, Sung Woo Bldg., 1424-2, Seocho 1-dong, Seocho-gu, Seoul 137-864, Republic of Korea cDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea |
Abstract: | Proteins have various compositions of twenty specific naturally occurring amino acids. In spite of their importance in cellular metabolism, biosynthesis mechanisms, changing control conditions, and affection of effectors are not clearly understood yet. So we have made an effort to elucidate the details of metabolic control mechanisms in amino acid synthesis pathways through examining an extensive database search. In this study, we have newly constructed six amino acid biosynthesis pathways including aspartate, asparagine, methionine, threonine, isoleucine, and lysine, which we call the aspartate family. They contain the major reaction mechanisms, which inhibitory control loops and activating compounds. Moreover, we have tried to collect all of the effectors which might affect the aspartate family biosynthetic networks. |