Association of the HindIII Polymorphism of the Lipoprotein Lipase Gene with Myocardial Infarction and the Life Span in Elderly Patients with Coronary Heart Disease |
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| Authors: | N A Malygina A S Melent'ev I V Kostomarova I A Melent'ev R T Saigitov Yu B Smirnova L D Serova |
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| Institution: | (1) Institute of Gerontology, Ministry of Health of the Russian Federation, Moscow, 117437, Russia;(2) Ministry of Health of the Russian Federation, Russian State Medical University, Moscow, 117437, Russia;(3) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia |
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| Abstract: | Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H– being protective. The allele and genotype frequencies of long-lived people differed significantly from the Hardy–Weinberg proportions and from those of SAE patients aged up to 90. An excess of heterozygotes in this group suggests a selective pressure which eliminates homozygotes. Possibly, heterozygotes H+/H– have an adaptive advantage, which provides for their longevity. |
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| Keywords: | HindIII polymorphism lipoprotein lipase gene myocardial infarction long-lived individuals |
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