Association of polymorphic markers of the lipid metabolism genes with diabetic polyneuropathy in type 1 diabetes mellitus |
| |
Authors: | O E Voron’ko N Yu Yakunina I A Strokov I N Lavrova V V Nosikov |
| |
Institution: | (1) State Research Center GosNIIGenetika, Moscow, 117545, Russia;(2) Sechenov Moscow Medical Academy, Moscow, 119021, Russia;(3) Russian Medical Academy of Postgraduate Education, Moscow, 125315, Russia |
| |
Abstract: | A possible association of the polymorphic markers 2/3/4 of the apolipoprotein E gene (APOE) and I /D of the apolipoprotein B gene (APOB) with diabetic polyneuropathy (DPN) was analyzed in patients with type 1 diabetes mellitus (T1DM) with (N=86) or without (N=94) clinical signs of DPN. The two groups did not differ significantly in allele and genotype frequencies of the 2/3/4 polymorphic marker of the APOE gene. Analysis of the allele and genotype frequency distributions of the I/D polymorphic marker of the APOB gene showed that risk of DPN is higher in carriers of allele I or genotype I/I (OR=1.66 and 2.01, respectively) and lower in carriers of allele D (OR=0.60). The results implicate the APOB gene, which codes for one of the major components of the lipid metabolism system, in DPN development in patients with T1DM.__________Translated from Molekulyarnaya Biologiya, Vol. 39, No. 2, 2005, pp. 230–234.Original Russian Text Copyright © 2005 by Voronko, Yakunina, Strokov, Lavrova, Nosikov. |
| |
Keywords: | type 1 diabetes mellitus diabetic polyneuropathy polymorphic markers APOE APOB polymerase chain reaction human |
本文献已被 SpringerLink 等数据库收录! |
|