首页 | 本学科首页   官方微博 | 高级检索  
   检索      

阿司匹林增加胰岛素抵抗大鼠胰岛素敏感性的实验研究
引用本文:童国玉,李果,李纪平,刘赟,张宏利.阿司匹林增加胰岛素抵抗大鼠胰岛素敏感性的实验研究[J].中国实验动物学报,2004,12(2):112-115.
作者姓名:童国玉  李果  李纪平  刘赟  张宏利
作者单位:上海第二医科大学附属瑞金医院,上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心,上海,200025
摘    要:目的 观察阿司匹林对高脂饮食大鼠胰岛素敏感性的影响。方法 灌服阿司匹林前后采用腹腔注射胰岛素耐量试验 (IITT)观察大鼠胰岛素的敏感性 ,并测定空服胰岛素、血糖和血脂等。结果 高脂饮食 4月、阿司匹林治疗 4周后 ,IITT发现高脂组腹腔注射胰岛素后 1h、1 5h和 2h的血糖及空腹胰岛素和甘油三酯水平显著高于正常对照组 (P <0 0 5或P <0 0 1 ) ;而阿司匹林治疗组腹腔注射胰岛素后 1h、1 5h和 2h的血糖及空腹胰岛素和甘油三酯水平显著低于高脂组 (P <0 0 5或P <0 0 1 ) ,与正常对照组差异无显著性。结论 大剂量阿司匹林有增加胰岛素敏感性和改善脂代谢紊乱的作用

关 键 词:阿司匹林  胰岛素  胰岛素抵抗
文章编号:1005-4847(2004)02-0112-04
修稿时间:2003年10月13

Experimental Study on Aspirin Raised Insulin Sensitivity in Insulin Resistance Rat
TONG Guo yu,LI Guo,LI Ji ping,LIU Yun,ZHANG Hong li.Experimental Study on Aspirin Raised Insulin Sensitivity in Insulin Resistance Rat[J].Acta Laboratorium Animalis Scientia Sinica,2004,12(2):112-115.
Authors:TONG Guo yu  LI Guo  LI Ji ping  LIU Yun  ZHANG Hong li
Abstract:Objective To observe the effects of aspirin on insulin sensitivity in high fat fed rats. Methods Before and after ingesting aspirin, intraperitoneal insulin tolerance test was used to measure the insulin sensitivity, and fasting blood glucose, insulin and blood lipid were determined. Results Fat fed rats had similar glucose concentration to chow fed rats, but significantly higher levels of insulin, triglyceride(TG) and 1 h,1 5 h,2 h blood glucose concentration after intraperitoneal insulin tolerance test. Serum levels of insulin,TG and 1 h,1 5 h,2 h blood glucose concentration after intraperitoneal insulin tolerance test of fat fed rats treated with aspirin were significantly lowered. Conclusion It is confirmed that aspirin could raise insulin sensitivity of high fat fed rats.
Keywords:Aspirin  Insulin sensitivity  Insulin resistance
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号