| 椎间盘脱出大鼠模型的脊髓血流量变化及电针效应 |
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| 引用本文： | 卢知松,陈益山,姜代勋,李格宾,孙胜永,穆祥,陈武.椎间盘脱出大鼠模型的脊髓血流量变化及电针效应[J].中国实验动物学报,2011,19(5):381-386. |
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| 作者姓名： | 卢知松 陈益山 姜代勋 李格宾 孙胜永 穆祥 陈武 |
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| 作者单位： | 1. 北京农学院兽医学(中医药)北京市重点实验室,北京,102206
2. 北京农学院动物科学技术学院,北京,102206 |
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| 摘 要： | 目的 观察大鼠椎间盘脱出模型的脊髓血流量及其电针效应,为兽医临床犬椎间盘病病理和针灸作用机理研究积累资料.方法 通过外科手术将硅胶片填充于大鼠第13胸椎( T13)脊髓腹侧位制作胸腰段椎间盘脱出模型,通过激光散斑血流系统实时监测造模后第一腰椎(L1)脊髓背侧血流量及电针刺激双侧足三里穴和趾间穴对其的影响.结果 以硅胶片填充于大鼠T13的脊髓腹侧位可成功制作出类似犬胸腰段椎间盘脱出的后肢瘫痪模型,且重复性好；模型组大鼠在压迫后,L1段的脊髓背侧血流量呈极显著下降(P＜0.01),电针双侧足三里穴和趾间穴可显著升高血流量(P＜0.05),电针结束后约10 min其血流量逐渐恢复至电针前水平；电针组大鼠电针治疗14 d后,脊髓背侧血流量极显著高于对照组,且运动功能评分显示电针组大鼠的后肢运动功能显著改善.结论 通过外科手术将硅胶片填充于大鼠T13脊髓腹侧位可成功制作胸腰段椎间盘脱出模型；压迫后L1段脊髓血流量显著下降；电针治疗后脊髓血流量极显著升高,且瘫痪大鼠运动机能明显好转,这可能与电针改善脊髓血流量继而减轻脊髓损伤并促进损伤恢复或促进代偿机制有关.
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| 关 键 词： | 椎间盘脱出模型 脊髓血流量 电针 运动功能 大鼠 |
Changes of the spinal cord blood flow in rat models of intervertebral disc extrusion and the effect of electroacupuncture |
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| LU Zhi-song,CHEN Yi-shan,JIANG Dai-xun,LI Ge-bin,SUN Sheng-yong,MU Xiang,CHEN Wu.Changes of the spinal cord blood flow in rat models of intervertebral disc extrusion and the effect of electroacupuncture[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(5):381-386. |
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| Authors: | LU Zhi-song CHEN Yi-shan JIANG Dai-xun LI Ge-bin SUN Sheng-yong MU Xiang CHEN Wu |
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| Institution: | LU Zhi-song1,CHEN Yi-shan1,JIANG Dai-xun1,LI Ge-bin2,SUN Sheng-yong2,MU Xiang1,CHEN Wu2(1.Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,2.Department of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China) |
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| Abstract: | Objective To observe the changes of spinal cord blood flow(SCBF) in rat models of intervertebral disc extrusion and the effects of electroacupuncture(EA),and to get better understanding the pathology of canine intervertebral disc disease and the mechanism of acupuncture treatment in veterinary clinics.Methods Thirty seven male adult Sprague Dawley rats were randomly divided into 3 groups: the normal control group(9 rats),model control group(14 rats) and electroacupuncture-treated model group(14 rats).First,... |
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| Keywords: | Intervertebral disc extrusion model Spinal cord blood flow Electroacupuncture Motor function Rat |
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