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冠脉结扎法制做大鼠心肌缺血模型
引用本文:周文武,林玲,陈军,杨进福,周新民,胡建国.冠脉结扎法制做大鼠心肌缺血模型[J].中国实验动物学报,2004,12(4):226-230.
作者姓名:周文武  林玲  陈军  杨进福  周新民  胡建国
作者单位:1. 中南大学湘雅二医院胸心外科,长沙,410011
2. 中南大学湘雅二医院心内科
3. 中南大学湘雅二医院实验动物中心
基金项目:湖南省科技计划项目(03TCY2012)。
摘    要:目的探讨大鼠心肌缺血动物模型的构建。方法缝扎大鼠冠脉左前降支,于左室前外侧壁形成缺血区域,约占左室壁面积的20%~50%。结果完成85例动物模型制作,存活74只,其中60只据术中所见、心电图、及病理检查证实有明确的心肌缺血,心功能下降。结论该方法制作简单可行,动物存活率满意;但模型欠稳定,需标本量较大以充分筛选。

关 键 词:心肌缺血  模型  动物  冠状动脉硬化
文章编号:1005-4847(2004)04-0226-05
修稿时间:2004年2月25日

Structure of Ischemic Heart Model in Rats by Coronary Artery Ligation
ZHOU Wen wu ,LIN Ling ,CHEN Jun ,YANG Jin fu ,ZHOU Xin min ,HU Jian guo.Structure of Ischemic Heart Model in Rats by Coronary Artery Ligation[J].Acta Laboratorium Animalis Scientia Sinica,2004,12(4):226-230.
Authors:ZHOU Wen wu  LIN Ling  CHEN Jun  YANG Jin fu  ZHOU Xin min  HU Jian guo
Institution:ZHOU Wen wu 1,LIN Ling 2,CHEN Jun 3,YANG Jin fu 1,ZHOU Xin min 1,HU Jian guo 1
Abstract:Objective To discuss the method of establishment of cardiac ischemic model in rats. Methods The left anterior descending coronary artery (LAD) was ligated to form an ischemic area which located at the anterolateral left ventricular free wall, accounting for 20%-50% of it. Results\ 85 animals' LAD were stitched, and 74 survived. Among these survived animals, 60 with heart dysfunction were confirmed as qualified ischemic model by operative observation, electrocardiogram and histopathology. Conclusion\ This method can easily create the ischemic heart model with acceptable death rate, but the model's stability is varying, which requires more candidate samples.
Keywords:Myocardial ischemia  Model  animal  Coronary arteriosclerosis
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