| 去垂体幼鼠的生物学特性与激素水平 |
| |
| 引用本文： | 刘应科,张知新,李鸿,苏慧敏,张琼,赵秋玲,郭建.去垂体幼鼠的生物学特性与激素水平[J].中国实验动物学报,2011,19(3):259-262,275. |
| |
| 作者姓名： | 刘应科 张知新 李鸿 苏慧敏 张琼 赵秋玲 郭建 |
| |
| 作者单位： | 1. 中日友好医院儿科,北京,100029
2. 中日友好医院临床研究所,北京,100029 |
| |
| 基金项目： | 儿科中青年内分泌医师科研基金项目 |
| |
| 摘 要： | 目的观察去垂体幼鼠的生物学特性的改变,了解去垂体术后幼鼠体内激素水平。方法 80只4周龄SD幼鼠2 d内经咽旁入路行垂体去除术,术后与20只同批系的正常幼鼠置于相同条件下观察并饲养,隔日记录体重、饮水量、进食量、体长、尾长等,1周时测量体温后,放入代谢笼饲养1d,记录尿量,2周时测量体温并经目眦静脉采血,分离冻存,分批测量生长激素(GH)、类胰岛素生长因子-1(IGF-1)、甲状腺激素(FSH、FT3、FT4)、促肾上腺皮质激素(ACTH)等。结果去垂体术后2周中,生物特性明显改变,体重、身长、尾长增长,与正常大鼠比较,去垂体幼鼠存在生长障碍,体温逐渐下降,进食量减低,饮水量、排尿量增加。血清GH、IGF-1、ACTH、FSH、FT3、FT4降低,与对照组相比差异有显著性(P<0.01)。结论去垂体幼鼠生物特性改变,垂体激素水平显著降低。
|
| 关 键 词： | 去垂体 幼鼠 生物特性 激素水平 |
Biological characteristics and hormonal alterations in hypophysectomized immature rats |
| |
| LIU Ying-ke,ZHANG Zhi-xin,LI Hong,SU Hui-min,ZHANG Qiong,ZHAO Qiu-ling,GUO Jian.Biological characteristics and hormonal alterations in hypophysectomized immature rats[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(3):259-262,275. |
| |
| Authors: | LIU Ying-ke ZHANG Zhi-xin LI Hong SU Hui-min ZHANG Qiong ZHAO Qiu-ling GUO Jian |
| |
| Institution: | LIU Ying-ke1,ZHANG Zhi-xin1,LI Hong2,SU Hui-min1,ZHANG Qiong1,ZHAO Qiu-ling1,GUO Jian2(1.Department of Pediatrics,2.Clinical Research Institute,China-Japan Friendship Hospital,Beijing 100029,China) |
| |
| Abstract: | Objective To observe the changes of the biological characteristics and hormonal alterations in hypophysectomized immature rats.Method Eighty 4-weeks old Sprague-Dawley young rats underwent hypophysectomy via parapharyngeal approach within two days,and among them 20 qualified operated rats were taken as the group A(experimental group).They were raised together with 20 control rats(group B) under the same conditions.Their body weight,drinking water volume,food intake amount,body length and tail length were re... |
| |
| Keywords: | Hypophysectomy Immature rats Biological characteristics Pituitary hormones |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
