长爪沙鼠血清雌性激素的比较研究

目的测定长爪沙鼠、NIH小鼠和SD大鼠的血清雌二醇(E2)和孕酮(P)水平,为研究长爪沙鼠的生殖和胚胎工程提供基础资料。方法用放射免疫分析法测定上述动物生产前后血清雌二醇(E2)和孕酮(P)水平,进行统计学处理和分析。结果不同阶段雌性沙鼠E2值差异无显著性(P>0.05),P值差异有显著性(P<0.01);E2值比较,处女期沙鼠与同期NIH和SD差异有显著性(P<0.01),而在经产期的动物间水平接近(P>0.05);P值比较,处女期沙鼠与NIH接近,与SD差异有显著性(P<0.01);而经产期沙鼠在三种动物中是最高的(P<0.01)。结论长爪沙鼠血清E2、P的含量具种属特异性,并随动物的生理发育时期而变化。

Estradiol and Progesterone in Blood Serum of Mongolian Gerbil

Objective To make measurement of the estradiol (E-2) and progesterone (P) level in blood serum of Mongolian gerbils, and to compare with those in NIH mice and SD rats. Method The serum E2 and P of these laboratory animals were measured by RIA and statistically analyzed. Results The serum level of E-2 in virginal and multiparous Mongolian gerbils is not significantly changed, and serum P is higher in multiparous gerbils (P<0.01). There is a significant difference between the E-2 level in virginal Mongolian gerbils and in NIH mice and SD rats (P<0.01), but similar in multiparous gerbils (P>0.05). The P level in virginal gerbils is similar to that of NIH mice, but significantly different with that in SD rats (P<0.01). The serum P level in multiparous gerbils is highest in comparison with that of NIH mice and SD rats (P<0.01). Conclusion The estradiol and progesterone levels in blood serum are species specific in Mongolian gerbils and change with the growth and development of the animals.