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| 长爪沙鼠速发型高脂血症模型的初步建立 | |
| 引用本文： | 钟民涛,黄敏,卢静,孟霞,王钜.长爪沙鼠速发型高脂血症模型的初步建立[J].中国实验动物学报,2006,14(3):217-221. |
| 作者姓名： | 钟民涛 黄敏 卢静 孟霞 王钜 |
| 作者单位： | 1. 首都医科大学实验动物科学部,北京,100054;大连医科大学微生物学教研室,大连,116027 2. 大连医科大学微生物学教研室,大连,116027 3. 首都医科大学实验动物科学部,北京,100054 |
| 基金项目： | 首都创新工程项目(248项目) |
| 摘 要： | 目的建立长爪沙鼠速发型高脂血症模型的方法。方法用含1%胆固醇高脂饲料分别饲养大鼠、小鼠和沙鼠,检测其血清TC、HDL-c、LDL-c、TG,比较三种动物对饲料反映的特点。结果沙鼠组的TC、HDL-c及LDL-c在第1周时明显的升高,并且平稳的保持此升高趋势到第四周。而TG数值相对平稳,没有变化。而大鼠和小鼠的TC、HDL-c、LDL-c、TG值没有变化。结论通过饲喂高脂饲料可快速诱发长爪沙鼠形成高脂血症模型。 |
| 关 键 词： | 沙鼠亚科 高脂血症 模型 动物 |
| 文章编号： | 1005-4847(2006)03-0217-05 |
| 修稿时间： | 2005年7月1日 |
Establishment of a Rapid Hyperlipidemic Gerbil Model |
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| ZHONG Min-tao,HUANG Min,LU jing,MENG xia,WANG Ju.Establishment of a Rapid Hyperlipidemic Gerbil Model[J].Acta Laboratorium Animalis Scientia Sinica,2006,14(3):217-221. | |
| Authors: | ZHONG Min-tao HUANG Min LU jing MENG xia WANG Ju |
| Abstract: | Objective To establish a rapid hyperlipidemic gerbil model.Methods Ten rats,ten mice and ten gerbils were fed with semipurified diet containing 1% cholesterol.Serum total cholesterol,triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the rats of the three groups were measured at the end of first,second,third and the fourth week and the data were compared among the 3 groups.Results Serum TC,LDL-c and HDL-c in gerbils reached a stable high level in the first week and were kept up to the fourth week,however,serum TG did not change significantly.Serum TC,TG,LDL-c and HDL-c in rats and mice were not changed.Conclusion Rapid hyperlipidemic model can be created in gerbils. |
| Keywords: | Hyperlipidemia Gerbil linae Model animal |
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