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| 卡维地洛对顺铂所致大鼠肾毒性预防作用的形态学研究 | |
| 引用本文： | 张艳梅,李春媚,张伟杰.卡维地洛对顺铂所致大鼠肾毒性预防作用的形态学研究[J].中国实验动物学报,2007,15(2):123-125. |
| 作者姓名： | 张艳梅 李春媚 张伟杰 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院病理科,哈尔滨,150086 2. 哈尔滨医科大学附属第二医院肾内科,哈尔滨,150086 3. 大庆市第五医院内科,大庆,163714 |
| 摘 要： | 目的研究顺铂诱导大鼠肾损伤的组织病理学和超微结构变化以及卡维地洛对大鼠肾损伤的预防作用。方法雄性Wistar大鼠随机分为4组,给药后3～6d处死,取肾组织,常规石蜡切片,HE染色、PAS反应,超薄切片电镜观察。结果卡维地洛组较顺铂肾脏损伤模型组的组织病理学及超微结构变化明显减轻。结论卡维地洛预防性灌胃给与能明显减轻大鼠顺铂所致的肾损伤,其机制可能与其抗氧化和清除自由基活性有关。 |
| 关 键 词： | 卡维地洛 顺铂 肾毒性 形态学 大鼠 |
| 文章编号： | 1005-4847(2007)02-0123-03 |
| 修稿时间： | 2006年9月25日 |
Morphological Study on the Protective Effect of Carvedilol on Cisplatin-Induced Renal Toxicity in Rats |
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| ZHANG Yan-mei,LI Chun-mei,ZHANG Wei-jie.Morphological Study on the Protective Effect of Carvedilol on Cisplatin-Induced Renal Toxicity in Rats[J].Acta Laboratorium Animalis Scientia Sinica,2007,15(2):123-125. | |
| Authors: | ZHANG Yan-mei LI Chun-mei ZHANG Wei-jie |
| Abstract: | Objective To investigate the protective effect of carvedilol on renal toxicity induced by cisplatin(CP).Method Male Wistar rats were randomly divided into four groups:saline control group,carvedilol control group,CP group and carvedilol protection group.The rats were killed at 3 to 6 days after drug administration.The kidney tissues were examined by light(HE and PAS staining)and electron microscopy.Results The renal histopathological and ultrastructural damages were markedly alleviated in the carvedilol protection group in comparison with those in the CP group.Conclusion By intragastric administration of carvedilol,obvious protective effect can be achieved on the cisplatin-induced nephrotoxicity.Antioxidation,scanvaging of free radicals,and enhancement of the activities of some antioxidant enzymes may be involved in the mechanisms of action in this process. |
| Keywords: | Carvedilol Cisplatin Nephrotoxicity Morphology Rat |
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