| 失重状态下肌萎缩研究进展 |
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| 引用本文： | 张淑,袁明,吴士文.失重状态下肌萎缩研究进展[J].中国实验动物学报,2013(6):84-87. |
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| 作者姓名： | 张淑 袁明 吴士文 |
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| 作者单位： | [1]中国人民武装警察部队总医院神经内科,北京100039 [2]中国航天员科研训练中心,北京100094 |
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| 摘 要： | 失重条件下人和动物生理状态会发生一系列的变化,其中骨骼肌萎缩和力量下降较为显著,目前其发生的机制仍不明确且缺少特效的干预措施。本文从肌肉湿重及肌纤维横截面积的变化、肌纤维类型的变化、肌纤维超微结构的变化、肌梭的适应性变化四个方面进行简要阐述,探讨肌肉萎缩的可能发生机制。
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| 关 键 词： | 失重 骨骼肌 肌萎缩 综述 |
Skeletal muscle atrophy in microgravity |
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| ZHANG Shu;YUAN Ming;WU Shi-wen.Skeletal muscle atrophy in microgravity[J].Acta Laboratorium Animalis Scientia Sinica,2013(6):84-87. |
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| Authors: | ZHANG Shu;YUAN Ming;WU Shi-wen |
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| Institution: | ZHANG Shu;YUAN Ming;WU Shi-wen;Department of Neurology,General Hospital of Chinese Armed Police Forces;State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center; |
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| Abstract: | It is well known that muscle mass and strength are declined in response to actual and simulated microgravity exposure. Until now,the mechanism of muscle atrophy under microgravity is still unclear and there is no specific medical intervention. This review describes the effects and mechanisms of actual and simulated microgravity on muscle wet weight,muscle fiber cross-sectional area,muscle fiber type,muscle ultrastructural changes,and adaptive changes in muscle spindle,and to summarize the major effects of space travel or simulated microgravity on skeletal muscle atrophy. |
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| Keywords: | Microgravity Skeletal muscle Muscle atrophy Review |
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