| 人肠道病毒71型动物模型研究进展 |
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| 引用本文： | 刘江宁,张连峰.人肠道病毒71型动物模型研究进展[J].中国实验动物学报,2010,18(3):275-278,F0003. |
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| 作者姓名： | 刘江宁 张连峰 |
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| 作者单位： | 1. 中国医学科学院实验动物研究所,卫生部人类疾病比较医学重点实验室,北京,100021
2. 中国医学科学院实验动物研究所,卫生部人类疾病比较医学重点实验室,北京,100021;中国医学科学院实验动物研究所,国家中医药管理局人类疾病动物模型三级实验室,北京,100021 |
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| 基金项目： | 十一五传染病专项支持 |
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| 摘 要： | 人肠道病毒71型是婴幼儿手足口病的致病原之一,其严重的并发症可导致神经系统疾病,甚至死亡,是近期威胁中国儿童健康的因素之一。目前尚无临床疫苗可以预防该病毒感染,而EV71的动物模型是进行致病机理、疫苗评价和药物等研究的基础。本文对EV71的两种常用动物模型：小鼠和猕猴（Macaca mulatta）模型进行了描述,并对其在研究中的应用给与概括,为研究者选择合适的动物模型提供了依据。
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| 关 键 词： | 人肠道病毒71型 手足口病 模型 动物 |
Human Enterovirus 71 Infection in Experimental animals |
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| LIU Jiang-ning,ZHANG Lian-feng.Human Enterovirus 71 Infection in Experimental animals[J].Acta Laboratorium Animalis Scientia Sinica,2010,18(3):275-278,F0003. |
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| Authors: | LIU Jiang-ning ZHANG Lian-feng |
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| Institution: | 1.Key Laboratory of Human Diseases Comparative Medicine,Ministry of Health;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences(CAMS) ＆ Comparative Medicine Centre,Peking Union Medical Collage(PUMC),Beijing 100021,China;2.Key Laboratory of Human Diseases Animal Models,State administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,CAMS ＆ Comparative Medicine Centre,PUMC,Beijing 100021) |
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| Abstract: | Human enterovirus 71（EV71） is one of the major pathogens causing hand,foot and mouth disease in children.The serious complications can lead to neurological symptoms and even death.EV71 is one of the factors threatening the health of Chinese children recently.However,there is currently no vaccine available to prevent clinical infection of this virus.As animl models are the foundation for pathogenesis studies,vaccine and drug research on EV71 infection,in this paper,two commonly used animal model for EV71,mouse and rhesus monkey,are described and their applications in research are summarized.,to provide fundamentall information for researchers in selection of a suitable animal model. |
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| Keywords: | Human Enterovirus 71 Hand foot and mouth disease Model animal |
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