实验性X综合征大鼠模型的建立

目的　建立一种典型的X综合症动物模型。方法　雄性SD大鼠施行两肾一夹术后普通饲料喂养 4周 ,诱发肾性高血压 ,继以高果糖饲料喂养 4周 ,诱导建立X综合症模型。结果　术后 4周 ,大鼠仅出现收缩压升高 ,血糖、血脂未见明显改变。高果糖饲料喂养 4周后 ,大鼠出现高血糖、高胰岛素血症、胰岛素抵抗、高血压和高脂血症。结论　肾性高血压形成后高果糖饮食 1个月 ,可诱导SD大鼠出现典型的X综合症 ,为研究胰岛素抵抗及其伴随的心血管疾病提供了一种理想的动物模型。

A Novel Rat Model of Syndrome X

Objective To establish a typical rat model with syndrome X. Method Adult male SD rats were operated on two kidneys, one-clipped to induce renal h ypertension. After operation, the rats were fed with a common diet for 4 weeks, and subsequently a high fructose diet for 4 weeks to induce syndrome X. Results The systolic blood pressure (SBP) was significantly increased a t 4 weeks after operation, but blood glucose and lipid were not changed markedly . Howevever, after feeding with high fructose diet for 4 weeks, hyperglycemia, h yperinsulinemia, insulin resistance, hypertension and hyperlipidemia occurred in the SD rats. Conclusion On the basis of renal hypertention for med by operation on kidneys, syndrome X can be induced in SD rats by high fructo se diet for 1 month. it may provide an ideal animal model for investigating insu lin resistance and accompanying cardiovascular disorders.