| MPTP帕金森病动物模型研究进展 |
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| 引用本文： | 高云朝,林祥通.MPTP帕金森病动物模型研究进展[J].中国实验动物学报,2005,13(4):261-265. |
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| 作者姓名： | 高云朝 林祥通 |
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| 作者单位： | 复旦大学附属华山医院核医学科,上海,200040 |
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| 摘 要： | 用神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)制备的动物模型,无论在神经生化和病理组织学特征,还是在运动行为表现方面都酷似人帕金森病(PD),是目前研究PD的理想模型。对MPTP动物模型发病机制等方面的深入研究将有助于PD的防治。
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| 关 键 词： | 帕金森病 1-甲基-4-苯基-1 2 3 6-四氢吡啶 模型 动物 |
| 文章编号： | 1005-4847(2005)04-0261-05 |
| 修稿时间： | 2004年5月27日 |
Progress in MPTP-Induced Animal Models of Parkinson's Disease |
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| GAO Yun-chao,LIN Xiang-tong.Progress in MPTP-Induced Animal Models of Parkinson's Disease[J].Acta Laboratorium Animalis Scientia Sinica,2005,13(4):261-265. |
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| Authors: | GAO Yun-chao LIN Xiang-tong |
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| Abstract: | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models are ideal models of human Parkinson's disease, in terms of neurobiochemical and histopathological changes, as well as behavioral disorders. Intensive research into the pathogenesis and other fields of MPTP-induced lesions in the animal models will contribute much to the prevention and cure of human Parkinson's disease. |
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| Keywords: | Parkinson's disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Model animal |
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