| 金黄地鼠与白化地鼠遗传生化基因位点概貌 |
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| 引用本文： | 王冬平,崔晓霞,尚世臣,陈旖,张小飞,陈振文,王全新,黄斌,尙玉璞,李桂军.金黄地鼠与白化地鼠遗传生化基因位点概貌[J].中国实验动物学报,2014(6):40-42. |
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| 作者姓名： | 王冬平 崔晓霞 尚世臣 陈旖 张小飞 陈振文 王全新 黄斌 尙玉璞 李桂军 |
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| 作者单位： | 军事医学科学院实验动物中心;首都医科大学实验动物科学部;辽宁长生生物技术有限公司; |
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| 基金项目： | 国家自然科学基金项目(No.3137227);军事医学科学院实验动物中心青年基金 |
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| 摘 要： | 目的建立金黄地鼠和白化地鼠遗传生化基因位点。方法选用小鼠和大鼠的遗传生化基因位点,采用蛋白质和同工酶醋酸纤维电泳的方法,对金黄地鼠和白化地鼠进行生化基因位点检测。结果建立了金黄地鼠和白化地鼠25个生化基因位点,分析金黄地鼠和白化地鼠遗传生化基因位点的多态性,为进一步研究金黄地鼠白化突变系的遗传机理奠定基础。结论金黄地鼠生化基因位点存在多态性,白化地鼠与金黄地鼠生化基因位点存在差异。
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| 关 键 词： | 金黄地鼠 白化地鼠 遗传 生化基因位点 |
Overview of genetic and biochemical loci in Mesocricetus auratus and its albino mutant |
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| Institution: | WANG Dong-ping, CUI Xiao-xia, SHANG Shi-chen, CHEN Yi, ZHANG Xiao-fei, CHEN Zhen-wen, WANG Quan-xin, HUANG Bin, SHANG Yu-pu, LI Gui-jun (1. Laboratory Animal Center, Military Academy of Medical Sciences, Beijing 100071, China; 2. Department of Laboratory Animals, Capital Medical University, Beijing 100069; 3. Liaoning Changsheng Biotechnology Co. Ltd. Benxi 117004) |
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| Abstract: | Objective To establish the genetic and biochemical loci in Mesocricetus auratus and its albino muatant.Methods Protein isozyme cellulose acetate electrophoresis was used to determine the genetic and biochemical loci in Mesocricetus auratus and its albino mutant, using the genetic and biochemical loci of mice and rats.Results 25 biochemical markers of Mesocricetus auratus and albino mutant were established, and polymorphism of their genetic biochemical loci was analyzed.Conclusions Polymorphism of biochemical loci is present in Mesocricetus auratus.Some differences exist between the genetic biochemical loci of Mesocricetus auratus and their albino mutant.These results laid the foundation for further study on genetic mechanism of albino mutation in Mesocricetus auratus. |
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| Keywords: | Mesocricetus auratus Albino mutant Genetic biochemical loci Mutation |
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