Inhibition of ATPases by gymnemic acid |
| |
Authors: | R B Koch D Desaiah L K Cutkomp |
| |
Institution: | 1. Department of Entomology, Fisheries and Wildlife, University of Minnesota, St. Paul, Minn. 55101 U.S.A. |
| |
Abstract: | A specially prepared and partially fractionated preparation of gymnemic acid compounds were found to be inhibitory to the ATPase system from housefly brain and labellum, and fish brain. Enzyme activity in a homogenate fraction from labellum showed greatest sensitivity to the gymnemic acid preparation. Na+-K+ ATPase activity from the labellum, which contains the sweet taste sensory receptors, was inhibited by over 92% at a concentration of 4 middot; 10?6M gymnemic acid. Because gymnemic acid compounds are specific suppressants of sweet receptors, the evidence presented in this paper implies that a portion of the ATPase system may be biochemically important in the sweet-sensing mechanism. |
| |
Keywords: | BSA bovine serum albumin PEP phosphoenolpyruvate |
本文献已被 ScienceDirect 等数据库收录! |
|