Genome research and evolution in trypanosomes |
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Authors: | John E Donelson |
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Institution: | Department of Biochemistry, University of Iowa and Howard Hughes Medical Institute, Iowa City, Iowa 52242, USA |
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Abstract: | Trypanosoma brucei and Trypanosoma cruzi cause different human diseases. As strategies for immune evasion. T. brucei undergoes antigenic variation whereas T. cruzi becomes an intracellular organism. This fundamental difference is reflected by major differences in their genome organizations. Recent comparisons of their gene sequences indicate that these two trypanosome species are highly divergent evolutionarily. |
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