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Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32. |
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| Authors: | W T Schroeder M F Miller S L Woo and G F Saunders |
| Abstract: | In situ hybridization of a recombinant cDNA probe containing the human alpha 1-antitrypsin gene to metaphase chromosomes demonstrated significant hybridization to chromosomal segment 14q31-32. A high percentage of cells analyzed (31%) displayed labeling on chromosome 14. Of all labeled sites on chromosome 14, 60% were found on segment 14q31-32. These results refine the previous assignment of the human alpha 1-antitrypsin gene to segment 14q24.1-32.1. |
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