| 大鼠急性应激时肝线粒体质子跨膜转运活性的调控 |
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| 引用本文： | 王学敏,缪明永,陈克明,焦选茂,朱丽萍,刘树森.大鼠急性应激时肝线粒体质子跨膜转运活性的调控[J].中国生物化学与分子生物学报,1993,9(6):725-729. |
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| 作者姓名： | 王学敏 缪明永 陈克明 焦选茂 朱丽萍 刘树森 |
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| 作者单位： | 第二军医大学生物化学教研室，第二军医大学生物化学教研室，第二军医大学生物化学教研室，中国科学院动物研究所细胞生物学室，中国科学院动物研究所细胞生物学室，中国科学院动物研究所细胞生物学室 上海 200433，上海 200433，上海 200433，北京 100080，北京 100080，北京 100080 |
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| 摘 要： | 大鼠烫伤早期(烫伤后30min),肝线粒体质子和电子传递速度均加快,线粒体能化态跨膜电位降低(均以琥珀酸为底物),线粒体膜脂流动性降低。皮下注射去甲肾上腺素后也有上述现象发生。推测急性应激通过儿茶酚胺类作用于肝细胞,导致线粒体内膜有序性增强所致。
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| 关 键 词： | 烧伤 线粒体 氧化磷酸化 跨膜电位 膜流动性 |
| 收稿时间： | 1993-12-20 |
Regulation of H'Transmembrane Transport Activity in Rat Liver Mitochondria During Acute Stress |
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| Wang,Xue-min Miao,Ming-yong Chen,Ke-ming.Regulation of H'Transmembrane Transport Activity in Rat Liver Mitochondria During Acute Stress[J].Chinese Journal of Biochemistry and Molecular Biology,1993,9(6):725-729. |
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| Authors: | Wang Xue-min Miao Ming-yong Chen Ke-ming |
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| Institution: | (Department of Biochemistry, 2nd Military Medical College, Shanghai, 200433) Jiao, Xuan-mao Zhu Li-ping Liu Shu-sen (Department of Cell Biology, Institute of Zoology, Academia sinica, Beijing,100080 |
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| Abstract: | Hydrogen ion pump and electron transfer rates were increased, and energized mitochondria transmembrane potential (△ψ), mitochondria inner membrane fluidity were decreased in rat liver mitochondria during the early phase of burn injury (30 min post-burn). Thirty minutes after subcutaneous injection of norepinephrine,the same phenomena mentioned above also happened. These phenomena were probably due to acute stress which increases the order of mitochondria inner membrane by catecholamines that act on liver cell. |
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| Keywords: | Burn8 Mitochondria Oxidative phosphorylation Mitochondria transmembrane potential Membrane fluidity |
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