| 接头蛋白Crk与肿瘤 |
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| 引用本文： | 田玉瑶,刘淑清.接头蛋白Crk与肿瘤[J].中国生物化学与分子生物学报,2014,30(11):1092-1097. |
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| 作者姓名： | 田玉瑶 刘淑清 |
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| 作者单位： | 北京大学医学部生物化学与分子生物学系;大连医科大学生物化学教研室 |
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| 基金项目： | 国家自然科学基金(No.81272186)资助项目~~ |
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| 摘 要： | Crk是一种重要的细胞内信号接头蛋白，含有SH2和SH3结构域，在信号传递过程中不仅承上启下，对信号强度还有着调控作用.迄今主要发现了4种Crk分子，即v Crk、CrkⅠ、CrkⅡ和CrkL(Crk Like).CrkⅡ和CrkL在分子结构上具有高度同源性，但对信号分子却具有不同的偏好性，从而体现出功能差异.本文就接头蛋白Crk的结构、Crk与相互作用蛋白质的作用机制以及与肿瘤的发生发展关系进行了阐述.
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| 关 键 词： | Crk Crk相关信号分子 接头蛋白 结构域 肿瘤 |
| 收稿时间： | 2014-03-28 |
The Roles of Adaptor Protein Crk in Cancer |
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| TIAN Yu-Yao;LIU Shu-Qing.The Roles of Adaptor Protein Crk in Cancer[J].Chinese Journal of Biochemistry and Molecular Biology,2014,30(11):1092-1097. |
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| Authors: | TIAN Yu-Yao;LIU Shu-Qing |
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| Institution: | TIAN Yu-Yao;LIU Shu-Qing;Department of Biochemistry & Molecular Biology,Peking University Health Science Center;Department of Biochemistry,Dalian Medical University; |
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| Abstract: | Crk, as an important signaling intracellular adaptor protein, contains a SH2 and a SH3 domain. Not only does Crk connect with up- and down-stream effectors, but also it regulates the signal intensity in the signal transduction process. So far, there are four main Crk molecules: v Crk, CrkⅠ, CrkⅡ and CrkL (Crk Like). CrkL and CrkⅡare highly homologous. However, they prefer to interact with different signaling factors, resulting in distinct functions. This review focuses on the structure of Crk,the mechanisms involved in Crk interaction and roles of Crk in carcinogenesis. |
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| Keywords: | Crk Crk related signaling molecules adaptor protein domain carcinoma |
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