| SFRP分子对心脏发育的影响 |
| |
| 引用本文： | 金雅琼,贾竹青,周春燕.SFRP分子对心脏发育的影响[J].中国生物化学与分子生物学报,2008,24(12):1103-1108. |
| |
| 作者姓名： | 金雅琼 贾竹青 周春燕 |
| |
| 作者单位： | 北京大学基础医学院生物化学与分子生物学系，北京100191 |
| |
| 摘 要： | Wnt信号通路对心脏发育起着重要的作用.分泌型卷曲相关蛋白（SFRP）家族作为调控 Wnt信号的重要分子，对心脏发育和心肌分化的作用也越来越被人们所重视.最近，研究人员们对SFRP家族蛋白有了新的认识，认为它们不仅具有拮抗Wnt的作用，还对Wnt信号的转导有着复杂的调节作用.本文就SFRP分子与Wnt信号转导对心脏发育的影响进行综述.
|
| 关 键 词： | 分泌型卷曲相关蛋白 Wnt 心脏发育 |
| 收稿时间： | 2008-7-7 |
SFRP Family and Cardiac Development |
| |
| JIN Ya-Qiong,JIA Zhu-Qing,ZHOU Chun-Yan.SFRP Family and Cardiac Development[J].Chinese Journal of Biochemistry and Molecular Biology,2008,24(12):1103-1108. |
| |
| Authors: | JIN Ya-Qiong JIA Zhu-Qing ZHOU Chun-Yan |
| |
| Institution: | DepartmentofBiochemistryandMolecularBiology,SchoolofBasicMedicalSciences,PekingUniversity,Beijing100191,China |
| |
| Abstract: | The Wnt pathways play crucial roles in cardiac development. The SFRP (secreted frizzled related protein) family, as a class of important Wnt signal regulators, has received increasing attentions for its roles in cardiac development and cardiomyocyte differentiation. Recent researches have discovered that SFRP appeared to have more complicated regulatory functions on Wnt signal transduction than just being a negative regulator. In this review, we will focus on the discussions of SFRP functions and the Wnt signaling during cardiac development. |
| |
| Keywords: | secreted frizzled related protein (SFRP) Wnt cardiac development |
|
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
| 点击此处可从《中国生物化学与分子生物学报》下载免费的PDF全文 |
