| 稀土对肌质网Ca~（2＋）－ATP酶活性的影响 |
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| 引用本文： | 李新民,倪嘉缵,王平原,陈建文,黄芬.稀土对肌质网Ca~（2＋）－ATP酶活性的影响[J].中国生物化学与分子生物学报,1995,11(3):281-285. |
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| 作者姓名： | 李新民 倪嘉缵 王平原 陈建文 黄芬 |
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| 作者单位： | 中国科学院长春应用化学研究所稀土化学与物理开放实验室，中国科学院生物物理研究所生物大分子国家重点实验室 |
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| 基金项目： | 国家攀登计划“稀土科学基础”资助 |
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| 摘 要： | 研究了镧、轧、镱及四种配合物对Ｃａ~（２＋）－ＡＴＰ酶活性的影响．结果表明，低浓度的Ｌａ~（３＋），Ｇｄ~（３＋）和Ｙｂ~（３＋）对肌质网Ｃａ~（２＋）－ＡＴＰ酶有激活作用；随着其浓度的增加，它们对酶活性的抑制程度增大；而Ｌａ~（３＋），Ｇｄ~（３＋）和Ｙｂ~（３＋）对纯化的Ｃａ２~（＋）－ＡＴＰ酶则只有抑制作用；Ｇｄ─Ｎ─乙酰─缬氨酸和Ｙｂ─丙氨酰代丙氨酸配合物对肌质网膜和纯化的Ｃａ~（２＋）－ＡＴＰ酶活性的影响与Ｇｄ~（３＋）及Ｙｂ~（３＋）类似，但其激活程度和抑制程度比Ｇｄ~（３＋）及Ｙｂ~（３＋）小；Ｇｄ─ＤＴＰＡ和Ｙｂ－ＤＴＰＡ对Ｃａ２~（＋）－ＡＴＰ酶活性基本无影响。
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| 关 键 词： | 稀土 肌质网 Ca~（2＋）－ATP酶 |
| 收稿时间： | 1995-06-20 |
Effects of Rare Earths on the Activity of Sarcoplasmic Reticulum Ca￣(2+)-ATPase |
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| Li Xin-Min,Ni Jia-Zuan.Effects of Rare Earths on the Activity of Sarcoplasmic Reticulum Ca￣(2+)-ATPase[J].Chinese Journal of Biochemistry and Molecular Biology,1995,11(3):281-285. |
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| Authors: | Li Xin-Min Ni Jia-Zuan |
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| Institution: | (Laboratory of Rare Earth Chemistry and Physics,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022)Wang Ping-Yuan;Chen Jian-Wen;Hwang Fen (National Laboratory of Biomacromolecules,Institute of Bio |
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| Abstract: | The effects of lanthanum, gadolinium, ytterbium and four kinds of complexes on the activity of Ca￣(2+)-ATPase were investigated. The results showed that low concentrations of La￣(3+),Gd￣(3+),Yb￣(3+)stimulated the SR ATPase activity and the activity was inhibited while increasing their concentrations,and La￣(3+),Gd￣(3+),Yb￣(3+) inhibited the purified ATPase activity. The effects of Gd-N-acetyl-valine and Yb-Alanyl-alanine complexes on the activities of the SR and purified ATPase were similar to that of Gd￣(3+)and Yb￣(3+),but the stimulation and inhibition were smaller than that of Gd￣(3+) and Yb￣(3+).There was no significant effect of Gd-DTPA and Yb-DTPA on the Ca￣(2+)-ATPase. |
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