| 家族性肾阳虚的基因功能富集分析 |
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| 引用本文： | 刘 明,丁维俊,蔡 欣,张天娥,李炜弘,王米渠.家族性肾阳虚的基因功能富集分析[J].中国生物化学与分子生物学报,2009,25(8):747-752. |
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| 作者姓名： | 刘 明 丁维俊 蔡 欣 张天娥 李炜弘 王米渠 |
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| 作者单位： | (1)四川大学华西医院生物治疗国家重点实验室,信号转导及分子靶向治疗研究室，成都610041；2)成都中医药大学，成都610075；3)成都铁路中心医院内分泌科，成都610081) |
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| 摘 要： | 在临床调查中筛选出一个典型肾阳虚证家系，选取典型肾阳虚证患者3例及家系内正常人3例进行表达谱芯片试验．芯片分析结果显示,肾阳虚证者表达上调基因106条，下调基因16条．通过基因功能分类及深入的基因功能富集分析发现,肾阳虚证与GnRH信号通路及氧化磷酸化密切相关（P≤005），从而为肾阳虚证本质的研究提供了新的思路，但具体的机制有待深入研究．
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| 关 键 词： | 肾阳虚证 基因功能富集分析 家系 氧化磷酸化 GnRH信号通路 |
| 收稿时间： | 2009-2-18 |
Gene Function Enrichment Analysis of a Pedigree with Typical Kidney-Yang Deficiency Syndrome |
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LIU Ming,DING Wei-Jun,CAI Xin,ZHANG Tian-E,LI Wei-Hong,WANG Mi-Qu
.Gene Function Enrichment Analysis of a Pedigree with Typical Kidney-Yang Deficiency Syndrome[J].Chinese Journal of Biochemistry and Molecular Biology,2009,25(8):747-752. |
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| Authors: | LIU Ming DING Wei-Jun CAI Xin ZHANG Tian-E LI Wei-Hong WANG Mi-Qu
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| Institution: | (1)Laboratory of Signal Transduction &; Molecular Targeting Therapy, State Key Laboratory of Biotherapy, West China Hospital,Sichuan University, Chengdu 610041, China;2) Chengdu University of TCM, Chengdu 610075, China;3) Department of Endocrine, Chengdu Railway Center Hospital, Chengdu 610081, China） |
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| Abstract: | A typical deficiency-cold syndrome pedigree were analyzed based on clinical investigation, and microarrays were made to examine expression profile of kidney-yang deficiency syndrome. Compared with normal members in the family, members with kidney-yang deficiency syndrome showed that there were 106 genes up-regulated and 16 down-regulated by at least 1.5 fold. Gene classification and gene function enrichment analysis of differentially expressed genes indicated that kidney-yang deficiency syndrome was closely associated with GnRH signaling pathway and oxidative phosphorylation (P≤005), but the exact mechanisms keeps unknown. |
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| Keywords: | kidney-yang deficiency syndrome gene function enrichment analysis pedigree oxidative phosphorylation GnRH signaling pathway |
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