乏氧微环境、“瓦伯格”效应及上皮间质转化相关性

肿瘤细胞在氧气充足的情况下以糖酵解的方式供能，这一现象称为“瓦伯格”效应，被认为是肿瘤的第七大特征。上皮间质转化（epithelial mesenchymal transition，EMT）是一种重要的细胞过程，参与胚胎发育、伤口愈合及肿瘤的发生等过程中，被认为是恶性肿瘤的重要特征。近年研究表明，“瓦伯格”效应和上皮间质转化的发生均与肿瘤处于乏氧微环境密切相关。乏氧微环境除可直接诱导上皮间质转化发生外，还可诱导肿瘤细胞产生“瓦伯格”效应，进一步促进上皮间质转化的发生。本文就乏氧微环境、“瓦伯格”效应、以及上皮间质转化的相关性的研究进展做一综述，有助于揭示乏氧微环境、肿瘤能量代谢改变以及肿瘤迁移侵袭之间的因果关联。

The Correlation of Hypoxic Tumor Microenvironment,Warburg Effect and Epithelial mesenchymal Transition#br#

The term “Warburg effect”, known as the seventh major feature of the tumor, describes the phenome that cancer cells exhibit glycolysis for energy even when enough oxygen is present. The epithelial-mesenchymal transition (EMT), as an important feature of malignancy, is a cellular program that is involved in embryonic development, wound healing, and tumorigenesis. Recently it has been proved that Warburg effect and EMT are both closely related to hypoxic tumor microenvironment. Hypoxic tumor microenvironment can not only directly induce EMT, but also induce Warburg effect to further promote EMT. In this paper, we discuss the correlation of hypoxic tumor microenvironment, Warburg effect and EMT, which may reveal the causal relationship among the hypoxic tumor microenvironment, the changes of energy metabolism, as well as tumor cells migration and invasion.