| 大鼠实验性帕金森病的基因治疗 |
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| 引用本文： | 曹蕾,蒋琼,郑仲承,孙兰英,刘新垣.大鼠实验性帕金森病的基因治疗[J].中国生物化学与分子生物学报,1996,12(6):637-640. |
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| 作者姓名： | 曹蕾 蒋琼 郑仲承 孙兰英 刘新垣 |
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| 作者单位： | 中国科学院上海生物化学研究所 |
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| 基金项目： | 863计划项目,国家自然科学基金 |
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| 摘 要： | 将稳定转染了大鼠酪氨酶羟化酶（Ｔｙｒｏｓｉｎｅｈｙｄｒｏｘｙｌａｓｅ，ＴＨ）基因的大鼠成肌细胞移植于帕金森病大鼠模型的纹状体，进行基因治疗研究。ＲＴ－ＰＣＲ和免疫组织化学检测都证明转基因细胞可在纹状体内存活并表达ＴＨ，动物的不对称旋转行为明显改善，而且疗效可维持半年以上。
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| 关 键 词： | 帕金森病 基因治疗 酪氨酸羟化酶 成肌细胞 脑移植 |
| 收稿时间： | 1996-12-20 |
The Experiment of Transgenic Therapy for Parkinson Disease in Rat |
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| Cao Lei,Jiang Qiong,Zheng Zhong-Cheng,Sun Lan-Ying, Liu Xin-Yuan.The Experiment of Transgenic Therapy for Parkinson Disease in Rat[J].Chinese Journal of Biochemistry and Molecular Biology,1996,12(6):637-640. |
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| Authors: | Cao Lei Jiang Qiong Zheng Zhong-Cheng Sun Lan-Ying Liu Xin-Yuan |
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| Institution: | (Shanghai Institute of Biochemistry, Shanghai 200031 |
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| Abstract: | Transgenic myoblast cell line L-6TG-TH which stably expresses rat tyrosine hydroxylase(TH) gene was transplanted into the striatum of the Parkinson disease (PD) rat model. RTPCR and immunohistochemical staining show that such transgenic myoblasts could survive and express TH gene in vivo. The asymmetrical rotation of PD rats model was reduced significantly by 65% and the effect lasted for at least 6 months.Other authors: Zhao Yin-Chun and Chen Sheng-Di (Rui Jin Hospital, Shanghai 200025 );Jiang Zhi-Hua and Zhou Chang-Fu (Shanghai Institute of Physiology, Academia Sinica, Shanghai 200031) |
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| Keywords: | Parkinson disease Gene therapy Tyrosine hydroxylase Myoblast cell line Intracerebral transplantation |
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