RGMb/DRAGON与BMP信号转导

RGMb/DRAGON为RGM家族成员之一，在许多组织和器官中存在并表达.最初它作为粘附分子在神经系统中调节轴突排斥被发现.近来研究发现,它还是BMP的辅助受体，与BMP配体和受体结合，通过调控BMP信号通路在繁殖、肾脏机能的维持以及免疫疾病等生理和病理条件下发挥重要作用.本文评述了RGMb的基因及蛋白结构特征、表达定位及其在神经系统中的作用，并重点介绍了其在BMP信号通路中的作用机制和生物学研究进展.

RGMb/DRAGON and BMP Signaling

RGMb/DRAGON, a member of the repulsive guidance molecule family, is originally found as an adhesion molecule to regulate axons repulsion and expressed in a variety of tissues and organs. Recently RGMb has been shown as a bone morphogenetic protein (BMP) co receptor, binding with BMP ligands and receptors, which play an important role in regulating BMP signaling activities under the physiological and pathological conditions such as the maintenance of reproduction, normal renal physiology and immune diseases. In this review, the genetic and protein structural characteristics, expression pattern of RGMb, and the roles in the nervous system, as well as the regulatory mechanisms and biological research progress in BMP signal transduction were summarized and discussed in detail.