| 稀土离子对磷脂酰胆碱脂质体及人红细胞膜自由基氧化的影响 |
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| 引用本文： | 王小芳,杨晓达,刘湘陶.稀土离子对磷脂酰胆碱脂质体及人红细胞膜自由基氧化的影响[J].中国生物化学与分子生物学报,1997,13(1):108-112. |
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| 作者姓名： | 王小芳 杨晓达 刘湘陶 |
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| 作者单位： | 北京医科大学无机教研室!北京，100083，北京医科大学无机教研室!北京，100083，北京医科大学无机教研室!北京，100083 |
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| 基金项目： | 国家自然科学基金，稀土基础研究基金 |
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| 摘 要： | 通过荧光和电泳方法研究了稀土离子对磷脂酰胆碱（PC）脂质体及人红细胞膜脂质过氧化的影响．结果表明稀土离子（除钇外）都能够强烈的抑制膜的脂质过氧化，其作用强度随不同的稀土离子可有较大的差别．稀土离子对分离的人红细胞膜的脂质过氧化的抑制作用比对PC脂质体更强．但是，对完整红细胞用稀土离子处理反而会导致膜的脂质过氧化大大加强．
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| 关 键 词： | 稀土离子 脂质过氧化 人红细胞膜 脂质体 |
| 收稿时间： | 1997-02-20 |
Effects of the Lanthanides on Membrane Oxidation of Liposome and Red Cell |
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| Wang Xiao-Fang,Liu Xiang-Tao,Yang Xiao-Da.Effects of the Lanthanides on Membrane Oxidation of Liposome and Red Cell[J].Chinese Journal of Biochemistry and Molecular Biology,1997,13(1):108-112. |
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| Authors: | Wang Xiao-Fang Liu Xiang-Tao Yang Xiao-Da |
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| Institution: | (Department of Inorganic Chemistry, School of Pharmaceutical Sciences,Beijing Medical University, Beijing 100083 |
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| Abstract: | The effects of the lanthanides on the oxidation of biological membrance were studied bythe methods of fluorornetry and SDS-PAGE. It were shown that lanthanides except Y(Ⅲ) inhibitthe hydrogen peroxide mediated peroxidation of PC liposome, "ghost" of human erythrocyte, andintact human erythrocyte. the effects of various Lns depend on their ionic radii. It is noteworthythat a pretreatment of the cells with Lns lead to an opposite effect: the peroxidation is evidentlyenhanced. |
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| Keywords: | Lanthanides Lipid peroxidation Erythrocyte Liposome |
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