| Ⅱa类组蛋白去乙酰化酶及抑制剂在胰岛素抵抗与糖尿病中的潜在作用 |
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| 引用本文： | 赵航,马慧娟,宋光耀.Ⅱa类组蛋白去乙酰化酶及抑制剂在胰岛素抵抗与糖尿病中的潜在作用[J].中国生物化学与分子生物学报,2018,34(12):1294-1298. |
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| 作者姓名： | 赵航 马慧娟 宋光耀 |
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| 作者单位： | 河北医科大学研究生院，石家庄050017；;河北医科大学内科教研室，石家庄050017；;河北省人民医院内分泌科，石家庄050051；;河北省代谢病重点实验室，石家庄050051 |
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| 基金项目： | 河北省自然科学基金重点项目（No. H2018307071） |
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| 摘 要： | Ⅱ类组蛋白去乙酰化酶(HDACs)包括HDAC4、5、7和9，它们能够发生磷酸化作用和介导核质转位。HDACs在肝、脂肪组织中的糖脂代谢中发挥作用，可加重胰岛素抵抗程度和糖尿病进展。Ⅱ类HDACs抑制剂目前已成为研究热点，旨在抑制酶活性，改善代谢和胰岛素敏感性。
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| 关 键 词： | 2型糖尿病 胰岛素抵抗 组蛋白去乙酰化酶 抑制剂 |
| 收稿时间： | 2018-06-12 |
The Class IIa Deacetylase and Its Inhibitors: Possible Therapies for Insulin Resistance and Type 2 Diabetes |
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| ZHAO Hang,MA Hui-Juan,SONG Guang-Yao.The Class IIa Deacetylase and Its Inhibitors: Possible Therapies for Insulin Resistance and Type 2 Diabetes[J].Chinese Journal of Biochemistry and Molecular Biology,2018,34(12):1294-1298. |
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| Authors: | ZHAO Hang MA Hui-Juan SONG Guang-Yao |
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| Institution: | Graduate School of Hebei Medical University, Shijiazhuang 050017, China;Department of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, China;Endocrinology Department, Hebei General Hospital, Shijiazhuang 050051, China;Hebei Key Laboratory of Metabolic, Shijiazhuang 050017, China |
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| Abstract: | Class II histone deacetylases (HDACs) include HDAC4, 5, 7 and 9, which are subject to phosphorylation, thereby regulating their nuclear and cytoplasmic translocation. They play a role in glycolipid metabolism in liver and adipose tissues, thus aggravating the degree of insulin resistance and the progression of diabetes. Inhibitors of class II HDACs have become a hot research topic. They aim to inhibit enzymatic activities, improve metabolism and insulin sensitivity. |
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| Keywords: | type 2 diabetes insulin resistance histone deacetylase(HDAC) inhibitor |
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