| 羟自由基对人红细胞氧化囊泡化的作用 |
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| 引用本文： | 冯立明,许彩民,方芳,卢红,刘晓冰,潘华珍.羟自由基对人红细胞氧化囊泡化的作用[J].中国生物化学与分子生物学报,1994,10(4):457-461. |
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| 作者姓名： | 冯立明 许彩民 方芳 卢红 刘晓冰 潘华珍 |
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| 作者单位： | 中国医学科学院基础医学研究所 |
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| 摘 要： | 红细胞经氧化处理后，发现红细胞膜区带１、２、２．１及３易形成高聚物，同时Ｈｂ亦有氧化变性。氧化过程中磷脂（ＰＳ、ＰＥ）逐渐减少，根据此结果提出氧化产生囊泡化的机制是：首先Ｈｂ氧化变性，膜骨架蛋白聚集，从而网架松散，膜磷脂脱离骨架的束缚，膜脂质与膜整合蛋白形成小囊泡从红细胞上脱落。
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| 关 键 词： | 红细胞 囊泡化 自由基 氧化损伤 |
| 收稿时间： | 1994-08-20 |
The Mechanism of Erythrocyte Vesiculation Induced by Oxidation in vitro |
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| Feng,Li-ming,Xu,Cai-min,Fang,Fang,Lu,Hong,Liu Xiao-bing,Pan,Hua-zhen.The Mechanism of Erythrocyte Vesiculation Induced by Oxidation in vitro[J].Chinese Journal of Biochemistry and Molecular Biology,1994,10(4):457-461. |
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| Authors: | Feng Li-ming Xu Cai-min Fang Fang Lu Hong Liu Xiao-bing Pan Hua-zhen |
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| Institution: | (Institute of Basic Medical Scienese,Beijing 100005 |
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| Abstract: | Erythrocytes were treated by oxidative agents aggregates of Band 1 , 2, 2. 1 ,& 3 were found in oxidation process. Hb was denatured and aggregated. Membrane phropholipids (PS, PE) decreased gradually during the process. The results suggested that the mechanism of vesiculation might be related to aggregate of membrame skeleton caused by Hb oxidation and then, phospholipids of bilayer were free from the bondage of skeleton,vesicles containing phospholipids and integral proteins were released from cytoskeleton. |
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| Keywords: | Erythrocytes Vesiculation Free radical Oxidative damage |
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