| 丹参酮Ⅱ－A磺酸钠对鼠肝线粒体功能的影响 |
| |
| 引用本文： | 焦选茂,周同庆,刘树森,缪明永,冯伟华,陈克明.丹参酮Ⅱ－A磺酸钠对鼠肝线粒体功能的影响[J].中国生物化学与分子生物学报,1995,11(3):292-296. |
| |
| 作者姓名： | 焦选茂 周同庆 刘树森 缪明永 冯伟华 陈克明 |
| |
| 作者单位： | 中国科学院动物研究所，第二军医大学生物化学教研室 |
| |
| 摘 要： | 利用大鼠肝脏线粒体为材料，以琥珀酸为底物，研究了不同浓度的丹参酮Ⅱ－Ａ磺酸钠对线粒体态４、态３呼吸及呼吸控制率，线粒体跨膜电位，线粒体呼吸链复合体（Ⅱ＋Ⅲ）电子传递及质子转移活性的影响。结果证明丹参酮ⅡＡ－磺酸钠是线粒体呼吸链复合体（Ⅱ＋Ⅲ）的有效抑制剂。文中对丹参酮ⅡＡ－磺酸钠在心肌缺血再灌注过程中的保护作用的分子机理进行了讨论。
|
| 关 键 词： | 丹参酮ⅡA－磺酸钠 线粒体 心肌缺血再灌注 |
| 收稿时间： | 1995-06-20 |
The Effects of Tenshone Ⅱ A-sulfonate on the Function of Rat Liver Mitochondria |
| |
| Jiao Xuan-Mao,Zhou Tong-Qing,Liu Shu-Sen.The Effects of Tenshone Ⅱ A-sulfonate on the Function of Rat Liver Mitochondria[J].Chinese Journal of Biochemistry and Molecular Biology,1995,11(3):292-296. |
| |
| Authors: | Jiao Xuan-Mao Zhou Tong-Qing Liu Shu-Sen |
| |
| Institution: | (State Key laboratory of Biomembrane and Membrane Biotechnology,Institute of Zoology,Academia,Sinica,Beijing 100080)Miao Ming-Yong;Feng Wei-Hua;Cheng Ke-Ming (Department of Biochemistry,Second Military Medical Coll |
| |
| Abstract: | The effects of tenshone Ⅱ A-sulfonate on the mitochondrial functions including respiratory control ratio,respiratory rate at state 4 and state 3,transmembrane potential,electron transfer and proton translocation activity of complex (Ⅱ+ Ⅲ) were studied. The results showed that tenshone Ⅱ A-sulfonate was an effective inhibitor of mitochondria respiratory chain. Based on these results,the mechanism of protection of tenshone A-sulfonate on myocardial injury in ischemia/repefusion process were discussed. |
| |
| Keywords: | TenshoneⅡ A-sulfonate Mitochondria Myocardial ischemia/reperfusion |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
| 点击此处可从《中国生物化学与分子生物学报》下载免费的PDF全文 |
