首页 | 本学科首页   官方微博 | 高级检索  
   检索      

手性环方铂络合物与DNA相互作用中的分子识别
引用本文:杨铭,胡齐悦,周田彦,崔景荣,张家美,王夔,王保怀.手性环方铂络合物与DNA相互作用中的分子识别[J].中国生物化学与分子生物学报,1998,14(5):599-603.
作者姓名:杨铭  胡齐悦  周田彦  崔景荣  张家美  王夔  王保怀
作者单位:北京医科大学天然药物及仿生药物国家重点实验室,北京大学化学与分子工程学院
基金项目:国家自然科学基金,博士点基金
摘    要:用生物微量热技术及DNATm测量研究了手性不同的三种环方铂络合物与小牛胸腺DNA(200bp)作用中的特异性,发现R,R构型的与DNA作用最强,这与癌细胞的体外筛选结果相一致.而且通过HPLC及13C-NMR研究为环方铂络合物与DNA作用的分子机理分析找到了直接的证据.

关 键 词:铂络合物  DNA  分子识别  
收稿时间:1998-10-20

Molecular Recognition of the Interaction between DNA and Chiral Cyclic Squaric Acid Pt Complexes
Yang Ming,Hu Qi,Yue,Zhou Tian,Yan,Cui Jing,Rong,Zhang Jia,Mei,Wang Kui.Molecular Recognition of the Interaction between DNA and Chiral Cyclic Squaric Acid Pt Complexes[J].Chinese Journal of Biochemistry and Molecular Biology,1998,14(5):599-603.
Authors:Yang Ming  Hu Qi  Yue  Zhou Tian  Yan  Cui Jing  Rong  Zhang Jia  Mei  Wang Kui
Institution:(National Research Laboratory of Natural and Biomimetic Drugs,Beijing Medical University,Beijing 100083) Wang Bao Huai (College of Chemistry and Molecular Engineering,P
Abstract:Specific interaction of CT DNA with three different chiral cyclic squaric acid Pt complexes were investigated by biomicrocalorimetric techniques and DNA T m measurements.The chiral features and steric chemistry of the newly synthesized complexes of their anticancer activity and the DNA molecular recognition were further studied.R,R Pt was found to be the most active in its interaction with DNA,which agreed with the results in the anticancer tests in vitro .Direct evidence for molecular mechanism of specific interaction of chiral cyclic squaric acid Pt complexes was found by HPLC and 13 C NMR studies.
Keywords:Pt complexes  DNA  Molecular recognition  
本文献已被 CNKI 等数据库收录!
点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息
点击此处可从《中国生物化学与分子生物学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号