| 影响动物细胞有丝分裂方向的因素应力纤维在纺锤体定位中的作用 |
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| 引用本文： | 赵磊,杨春,庄逢源.影响动物细胞有丝分裂方向的因素应力纤维在纺锤体定位中的作用[J].中国生物化学与分子生物学报,2010,26(11):981-987. |
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| 作者姓名： | 赵磊 杨春 庄逢源 |
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| 作者单位： | 北京航空航天大学生物与医学工程学院;清华大学航天航空学院; |
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| 基金项目： | 国家自然科学基金(No.30870602,No.30671098)资助项目~~ |
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| 摘 要： | 细胞的有丝分裂与细胞的增殖、分化及胚胎发育、组织器官形成、损伤组织的修复和疾病的发生有关.各种物理因素、细胞所处的微环境(包括细胞外基质、细胞粘附)等,以及胞内的多种信号因子均能对细胞的有丝分裂方向产生影响.大量文献表明,应力纤维的排列为有丝分裂中心粒分离和定位提供轨道,最终影响纺锤体和有丝分裂的定向.本实验室的micro-pattern和静态单轴拉伸应变实验进一步提示了应力纤维的排布方式是影响有丝分裂方向的重要因素.本文围绕着应力纤维的排布对有丝分裂方向的影响这一研究观点,综述分析了整合素介导的细胞外粘附-黏着斑的组装-应力纤维的排布-有丝分裂纺锤体定向等一系列影响贴壁哺乳动物细胞有丝分裂定向的过程.并根据酵母模型,对哺乳动物细胞有丝分裂定向过程的分子机制进行了介绍;在该过程中肌球蛋白、动力蛋白和kar9等蛋白质起到重要作用.
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| 关 键 词： | 哺乳动物细胞 有丝分裂 应力纤维 不对称分裂 |
| 收稿时间： | 2010-06-21 |
The Role of Stress Fiber in Spindle Positioning Affects the Orientation of Animal Cells Mitosis |
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| ZHAO Lei,YANG Chun,ZHUANG Feng-Yuan School of Biological Science , Medical Engineering,Beihang University,Beijing ,China, Institute of Biomechanics , Medical Engineering.The Role of Stress Fiber in Spindle Positioning Affects the Orientation of Animal Cells Mitosis[J].Chinese Journal of Biochemistry and Molecular Biology,2010,26(11):981-987. |
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| Authors: | ZHAO Lei YANG Chun ZHUANG Feng-Yuan School of Biological Science Medical Engineering Beihang University Beijing China Institute of Biomechanics Medical Engineering |
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| Institution: | ZHAO Lei1),YANG Chun2)*,ZHUANG Feng-Yuan1)(1) School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China,2) Institute of Biomechanics and Medical Engineering,Department of Mechanics Engineering,School of Aerospace,Tsinghua University,Beijing 100084,China) |
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| Abstract: | The cell orientation during mitosis is important for cell proliferation,differentiation,embryonic development,organogenesis,tissue injury recovery and disease generation.The factors in intracellular and extracellular microenvironment,such as extracellular matrix,cell adhesion,signal protein,etc.,may impact on the mitosis orientation.It is known that stress fibers form a scaffold to migrate the centrosomes to opposite sides and determines the spindle orientation of mitosis.An correlation between stress fiber... |
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| Keywords: | mammalian cell mitosis orientation stress fiber asymmetric division |
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