脂蛋白、载脂蛋白和脂蛋白受体与衰老

本文观察了新生儿(脐带血),青年(18—24岁),老年(55—65岁)各40例的血脂、脂蛋白、载脂蛋白和低密度脂蛋白LDL受体功能的变化。结果表明,新生儿的血脂,脂蛋白和载脂蛋白含量在各年龄组中最低(P<0.01),其LDL受体结合水平最高,(P<0.01)。血清TC,TG,LDL-C,apo B和CII随增龄上升,但LDL受体水平和HDL-C,apo AI,AII的增龄变化不明显。该结果指出,衰老对LDL受体的结合水平和HDL-C,apo AI,AII的影响似乎不大。另方面说明,TC,LDL-C和apo B浓度随增龄增加而不伴有相应的LDL受体结合水平及HDL-C,APO AI,AII浓度的上升,使老年期的脂蛋白代谢平衡被打破,因而促使高胆固醇血症和动脉粥样斑块的形成。

Relation Between Lipoprotein, Apolipoprotein, Lipoprotein Receptor and Senility

The changes of lipoprotein, apolipoprotein and LDL-receptor levels of 40 cases in each of the group of neonates (Cord blood), youth(aged 18-24 years), and elderly people(aged 55-65 years) respectively were observed.Results showed that the TC,TG,LDL-C, apo AI, AII,B and CII were found to be the lowest in neonates(P<0.01) but, LDL-receptor levels were the highest in all age groups(P<0.01) The serum values of TC,TG,LDL-C, apo B and CII increase with age, but the increased extent of apo B and CII were lower than that of TC and TG.The concentrations of HDL-C were not obviously increased with age.The serum values of apo AI and All rise gradually with growth(neonates-youth), but, the levels of LDL-receptor decrease gradually.The values are relatively stabilized from youth to old age.The results indicated that the influence of senility on LDL-receptor, apo AI, AH and HDL-C seems little, the values of TC, LDL-C and apo B increase with age, but the levels of LDL-receptor, HDL-C, apo AI and All do not rise correspondingly, Which suggest that the equilibrium of lipopiotein metabolism in the elderly are disturbed, a condition favourable for hypercholesterolemia and the formation atherosclerotic plaques.