| 环境内分泌干扰物对基因甲基化的影响 |
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| 引用本文： | 李海艳,蔡德培.环境内分泌干扰物对基因甲基化的影响[J].中国生物化学与分子生物学报,2014,30(1):38-43. |
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| 作者姓名： | 李海艳 蔡德培 |
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| 作者单位： | （复旦大学附属儿科医院, 上海201102） |
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| 基金项目： | 国家自然科学基金(No.30371820)资助 |
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| 摘 要： | 环境内分泌干扰物广泛地存在于人类的生存环境中,大多数具有显著的生殖毒性,不仅影响胚胎神经系统及生殖系统的发育,并可有传代效应及致癌作用.研究表明，环境内分泌干扰物大多是通过表观遗传学机制发挥其毒性作用. 目前,此方面的研究主要集中在胎儿及新生儿期暴露于内分泌干扰物对机体基因甲基化修饰的改变方面.本文就环境内分泌干扰物对胚胎发育的影响,及其传代效应和致癌作用在基因甲基化修饰调控方面作一综述.
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| 关 键 词： | 环境内分泌干扰物 表观遗传 甲基化 肿瘤 传代效应 |
| 收稿时间： | 2013-06-04 |
Environmental Endocrine Disruptors Affect DNA Methylation |
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| LI Hai-Yan,CAI De-Pei.Environmental Endocrine Disruptors Affect DNA Methylation[J].Chinese Journal of Biochemistry and Molecular Biology,2014,30(1):38-43. |
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| Authors: | LI Hai-Yan CAI De-Pei |
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| Institution: | （Children’s Hospital of Fudan University, Shanghai201102, China） |
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| Abstract: | Environmental endocrine disruptors (EEDs) widely exist in our living environment. With significant reproductive toxicity, these compounds not only affect embryonic development but also exhibit transgenerational inheritance effect and carcinogenesis effect. The most EEDs produce toxicity through epigenetic mechanisms focused on DNA methylation changes after explosing to EEDs at fatal or neonatal period. In this paper, the effects of EEDs on embryonic development, transgenerational inheritance and carcinogenesis at the aspect of DNA methylation modification regulatory mechanisms are reviewed. |
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| Keywords: | environmental endocrine disruptors (EEDs) epigenetic methylationt umor transgenerational inheritance effect |
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