A mathematical model of mechanical responses of contracting muscle fibers to temperature jumps |
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Authors: | N A Koubassova S Yu Bershitsky A K Tsaturyan |
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Institution: | 1. Institute of Mechanics, Moscow State University, Moscow, 119992, Russia
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Abstract: | A structural and kinetic model of actomyosin interaction in a contracting muscle fiber has been proposed, based on the assumption that the myosin molecular motor generates force in two steps. Initially, a nonstereospecifically attached myosin head rolls on the actin surface and stereospecifically locks on actin. Then its α-helical lever arm (neck domain) tilts about its catalytic domain. The model also includes the modern scheme of ATP hydrolysis by actomyosin. The results of modeling presented here quantitatively reproduce all experimentally observed characteristics of the responses of tension and stiffness of muscle fibers to T-jumps of different amplitudes. |
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