The interaction between dinitrosy iron complexes and intermediates of oxidative stress

The interaction between the glutathione-containing dinitrosyl iron complexes and the superoxide radical generated in mitochondria and in the xanthine-xanthine oxidase system was studied. Both superoxide and hydroxyl radicals proved to be involved in destruction of dinitrosyl iron complexes. However, the iron within dinitrosyl complexes is unlikely to catalyze decomposition of hydrogen peroxide yielding hydroxyl radical. It was found that iron dinitrosyl complexes with various anion ligands efficiently inhibited the formation of probucol phenoxyl radical in the hemin-H₂O₂ system, different components of these complexes being involved in the antioxidant action.