Brain protection by rapeseed oil in magnesium-deficient mice |
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Authors: | Pages Nicole Maurois Pierre Delplanque Bernadette Bac Pierre Martin Jean-Charles Du Qin Rapoport Stanley I Vamecq Joseph |
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Institution: | a NMPA, CNPS, Paris XI University, Orsay, France b Toxicology, Pharmacy, Strasbourg University, Illkirch, France c Neuropharmacology Laboratory, Faculty of Pharmacy, Châtenay Malabry, France and U999 Inserm, IFR 141, Centre Chirurgical Marie Lannelongue, F-92350 Le Plessis Robinson, France d Institut National de la Recherche Agronomique, UMR1260, Marseille, France e National Institutes of Health, Bethesda, MD, USA f Inserm, Dept of Prof. Nicole Porchet, Center of Biology and Pathology Pierre Marie Degand, CHRU Lille, France |
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Abstract: | Diets given for 30 days with various mono-(MUFA) and poly-(PUFA) unsaturated fatty acid contents were evaluated for brain protection in magnesium-deficient mice: a commercial and three synthetic diets (n-6PUFA, n-3PUFA and MUFA-based chows enriched with 5% corn/sunflower oils 1:3, with 5% rapeseed oil and with 5% high oleic acid sunflower oil/sunflower oil 7:3, respectively). Unlike magnesium deprivation, they induced significant differences in brain and erythrocyte membrane phospholipid fatty acid compositions. n-3PUFA but not other diets protected magnesium-deficient mice against hyperactivity and moderately towards maximal electroshock- and NMDA-induced seizures. This diet also inhibited audiogenic seizures by 50%, preventing animal deaths. Because, like n-6PUFA diet, matched control MUFA diet failed to induce brain protections, alpha-linolenate (ALA) rather than reduced n-6 PUFA diet content is concluded to cause n-3PUFA neuroprotection. Present in vivo data also corroborate literature in vitro inhibition of T type calcium channels by n-3 PUFA, adding basis to ALA supplementation in human anti-epileptic/neuroprotective strategies. |
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Keywords: | Polyunsaturated fatty acids Alpha-linolenic acid (ALA) Eicosapentaenoic acid (EPA) Rapeseed oil Brain protection Magnesium deficiency Hyperexcitability Chemical seizures Electrical seizures Audiogenic seizures Anticonvulsant Anti-inflammatory |
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