Effect of conjugated linoleic acid on body fat,tumor necrosis factor alpha and resistin secretion in spontaneously hypertensive rats |
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| Authors: | Guillermo Hernández-Díaz Alfonso Alexander-Aguilera Agustin Arzaba-Villalba Ida Soto-Rodríguez Hugo S García |
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| Institution: | 1. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA;2. Surgical Research, Department of General and Visceral Surgery, University Hospital, Muenster, Germany;3. Department of Pathology, Marion Bessin Liver Research Center, Diabetes Center, Cancer Center, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, and Institute for Clinical and Translational Research, Albert Einstein College of Medicine, Bronx, NY, USA;1. U.S. EPA, National Exposure Research Laboratory, Athens, GA 30605, USA;2. U.S. EPA, National Health and Environmental Effects Research Laboratory, Duluth, MN 55804, USA;3. University of St. Thomas, 2115 Summit Ave. Saint Paul, MN 55105, USA;1. Pathology, School of Medicine, Griffith University, Gold Coast, QLD 4222, Australia;2. Biology Department, College of Medicine, University of Dammam, Dammam 31451, Saudi Arabia |
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| Abstract: | Conjugated linoleic acid (CLA) is a naturally occurring group of dienoic derivaties of linoleic acid found mainly in beef and dairy products. CLA has been reported to reduce body fat, as well as to possess anticarcinogenic, antiatherogenic and procatabolic activities in animals. The objective of this study was to evaluate the effect of CLA supplementation to spontaneously hypertensive rats (SHR) on body fat, biochemical parameters of serum related tumor necrosis factor alpha (TNF-α) and resistin secretion. Thirty rats were divided in three groups, the first group of spontaneously hypertensive rats received a standard diet (V-SHR group, n=10), a second group of SHR was fed 1.5% of conjugated linoleic acid (CLA-SHR group, n=10) and the third was the control, non-hypertensive group (KW, n=10) also on a standard diet including 7.5% of sunflower oil during eight weeks.After CLA diet administration, spontaneously hypertensive rats showed a significant reduction in blood pressure, serum glucose, cholesterol and triacylglycerols, together with reduction of index of body fat, pericardic, abdominal and epididymal adipose tissue. These effects were accompanied by a decrease in the secretion of TNF-α and resistin. |
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