The role of D1-dependent dopaminergic mechanisms in the frontal cortex in the rat latent response |
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Authors: | Kozlov A P Druzin M Ia Kurzina N P Malinina E P |
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Institution: | Research Institute for Experimental Medicine, St.-Petersburg. |
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Abstract: | The effects of microinjections of D1 selective dopaminergic substances into the medial frontal cortex (MFC) on information storage and proactive interference during delayed (the delay in 3 s) and non-delayed choice in Y-maze were studied. Bilateral microinjection of D1 receptor antagonist SCH 23390 (1 nM, 1 microliter) impaired both delayed and non-delayed choice. In contrast, microinjections of D1 receptor agonist SKF 38393 (1 nM) into the MFC significantly improved the delayed performance and did not influence the non-delayed choice. The effects of proactive interference caused by SCH 23390 and SKF 38393 injections were more pronounced in delayed choice condition than in the non-delayed task. Spatial bias in animal behavior was revealed after the SCH 23390 injections: during erroneous choices rats more frequently turned in the same direction as preferred in a rotation test. The results suggest that impairment of delayed performance in Y-maze observed under the blockade of D1-mediated neurotransmission in the MFC occurs due to enhancement of the processes of proactive interference and disinhibition of the spatial set. |
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