自愿转轮运动对雄性长爪沙鼠体重和能量代谢的影响

运动是影响动物能量平衡和体重变化的重要因素之一。为研究自愿转轮运动对体重和能量代谢的影响,我们监测了8周自愿转轮运动过程中,雄性长爪沙鼠的体重、能量摄入、消化率、静止代谢率（RMR）和非颤抖性产热（NST）的变化,以及8周后的体脂含量、血清甲状腺激素（T3、T4）和瘦素（leptin）水平的变化等。结果发现,8周自愿转轮运动增加了长爪沙鼠的体重和能量摄入以及血清瘦素水平（血清瘦素浓度比对照组高27%）,但对消化率、RMR和褐色脂肪组织的线粒体蛋白浓度等没有明显影响。尽管体脂含量和血清T3和T4没有显著差异,但运动组体脂含量比对照组高33%,血清T3和T4水平分别比对照组低10%和38%。血清瘦素浓度与体脂重量呈正相关。因此,自动转轮运动并没有降低动物的体重和体脂含量,但瘦素和甲状腺素在雄性长爪沙鼠能量代谢和能量平衡中的作用尚需进一步确定。

Effects of voluntary wheel exercise on body mass and energy metabolism in male Mongolian gerbils (Meriones unguiculatus)

In order to explore the effects of voluntary wheel exercise on body mass and energy metabolism in male Mongolian gerbils(Meriones unguiculatus),we determined the body mass,energy intake,digestibility,resting metabolic rate(RMR),nonshivering thermogenesis(NST),body fat content,serum thyroid hormones(T3 and T4)and leptin concentrations in two groups,the control and the exercise group which are treated with 8-week-wheel running exercise.Body mass and energy intake increased in exercise group compared with control.Voluntary wheel exercise had no effects on digestibility,RMR,body fat content,serum leptin levels and T3 and T4 concentration,and mitochondrial protein content in brown adipose tissue,but the concentrations of T3 and T4 of wheel running gerbils were lower than those in the control by 10% and 38%,respectively,while the leptin levels and body fat mass increased by 27% and 33%,respectively.Serum leptin concentration was correlated positively with body fat mass but not related with energy intake.Altogether,voluntary wheel exercise stimulated the increase in body mass and food intake(exercise induced hyperphagia)but not in body fat contents in male Mongolian gerbils.The potential roles of leptin and thyroid hormones in the regulation of energy metabolism and energy balance in male Mongolian gerbils need to to be further studied.