Reconstruction of protein and nucleic acid sequences: IV. The algebra of free monoids and the fragmentation stratagem |
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Authors: | J E Mosimann M B Shapiro C R Merril D F Bradley J E Vinton |
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Institution: | (1) National Institutes of Health, Bethesda, Maryland |
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Abstract: | The problem of determining the sequence of a biopolymer from its fragments is stated in mathematical terms. Using concrete
properties of a free monoid, certain general classes of biopolymers are shown to be insolvable from fragment data produced
by complete digestion where enzymes specific for any possible combination of chemical bonds are employed.
The authors are grateful to Dr. Malcolm W. Oliphant, Department of Mathematics, Georgetown University, for his comments and
suggestions. |
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Keywords: | |
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