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Reconstruction of protein and nucleic acid sequences: IV. The algebra of free monoids and the fragmentation stratagem
Authors:J E Mosimann  M B Shapiro  C R Merril  D F Bradley  J E Vinton
Institution:(1) National Institutes of Health, Bethesda, Maryland
Abstract:The problem of determining the sequence of a biopolymer from its fragments is stated in mathematical terms. Using concrete properties of a free monoid, certain general classes of biopolymers are shown to be insolvable from fragment data produced by complete digestion where enzymes specific for any possible combination of chemical bonds are employed. The authors are grateful to Dr. Malcolm W. Oliphant, Department of Mathematics, Georgetown University, for his comments and suggestions.
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